' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
6.6
USERS' SCORE
Very Good
Based on 6 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
Vitamin D3 alleviates MS symptoms
Immunoregulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis (EAE) Mice.
Study focuses on vitamin D3 effects
We investigated the influence of calcitriol, the active form of vitamin D, on experimental autoimmune encephalomyelitis (EAE), an animal model akin to multiple sclerosis. Our study involved twenty-eight mice divided into four groups, allowing us to compare outcomes between those with and without EAE, as well as those receiving calcitriol treatment.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
Read More
8
Vitamin D3 influences MS immune response
The immune cell transcriptome is modulated by vitamin D supplementation in people with a first demyelinating event participating in a randomized placebo-controlled trial.
Direct assessment of immune impact
We conducted a thorough investigation into the potential benefits of vitamin D3 supplementation for individuals who have experienced a first demyelinating event, which can be an early indication of multiple sclerosis (MS). Our study was a part of the PrevANZ trial and involved randomizing participants to receive varying doses of vitamin D—1000, 5000, or 10,000 international units—or a placebo, over a period of 12 weeks.
We focused on how these vitamin D3 supplements affected the gene expression of immune cells. After analyzing blood samples from 55 participants both at the beginning and end of the study, we observed that higher doses of vitamin D significantly influenced immune cell activity. Specifically, we found pathways linked to antigen presentation and viral responses became more active, while pathways associated with energy production and certain immune signals, like tumor necrosis factor-alpha and interleukin-17, were less active.
Overall, the results indicate that vitamin D3 supplementation can lead to an anti-inflammatory shift in immune gene expression, suggesting a potential protective role in the development of MS. This study supports the hypothesis that vitamin D3 could be an effective strategy, showing a dose-dependent relationship in immune response modulation.
We focused on how these vitamin D3 supplements affected the gene expression of immune cells. After analyzing blood samples from 55 participants both at the beginning and end of the study, we observed that higher doses of vitamin D significantly influenced immune cell activity. Specifically, we found pathways linked to antigen presentation and viral responses became more active, while pathways associated with energy production and certain immune signals, like tumor necrosis factor-alpha and interleukin-17, were less active.
Overall, the results indicate that vitamin D3 supplementation can lead to an anti-inflammatory shift in immune gene expression, suggesting a potential protective role in the development of MS. This study supports the hypothesis that vitamin D3 could be an effective strategy, showing a dose-dependent relationship in immune response modulation.
Read More
7
Vitamin D3 reduces MS fatigue
Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
Highly relevant to MS treatment
We aimed to uncover the effect of vitamin D supplementation on fatigue in individuals with multiple sclerosis (MS) through a systematic review and meta-analysis. We examined studies that included randomized controlled trials, focusing on how these supplements might influence fatigue levels among patients.
In total, we analyzed five studies involving 345 participants, predominantly women, and ages ranging from 25.4 to 41.1 years. Our findings revealed a noteworthy reduction in fatigue when comparing vitamin D supplementation to a control group, suggesting that vitamin D3 could play a beneficial role in alleviating fatigue symptoms associated with MS.
While the results are promising, we noted some uncertainties regarding the optimal dosage of vitamin D to use. Therefore, it's essential that any supplementation is done under medical supervision. This approach ensures personalized care and the best possible outcomes.
In total, we analyzed five studies involving 345 participants, predominantly women, and ages ranging from 25.4 to 41.1 years. Our findings revealed a noteworthy reduction in fatigue when comparing vitamin D supplementation to a control group, suggesting that vitamin D3 could play a beneficial role in alleviating fatigue symptoms associated with MS.
While the results are promising, we noted some uncertainties regarding the optimal dosage of vitamin D to use. Therefore, it's essential that any supplementation is done under medical supervision. This approach ensures personalized care and the best possible outcomes.
Read More
Most Useful Reviews
8
Boosts immunity
Solar cell D3 is essential for everyone. It enhances immunity, reduces the risk of viral diseases, and is vital for various bodily functions. In our area, sunlight is limited, making D3 supplementation crucial. I prefer NOW Vitamin D3, as it offers excellent quality at a reasonable price.
Read More
8
Immunity enhancement
D3 is crucial for the immune system and reduces viral disease risks. It's synthesised in sunlight, so supplementation is important, especially during winter. I recommend NOW Vitamin D3 for its quality and value.
Read More
8.8
Supports brain health
Over 50? Take vitamin D3! It's excellent for bone health and prevents serious conditions like multiple sclerosis. The dosage works quickly, and I noticed positive effects soon after starting. Recommended for improving health!
Read More
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Based on 16 Researches
6.6
9
Vitamin D3 alleviates MS symptoms
Immunoregulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis (EAE) Mice.
Study focuses on vitamin D3 effects
We investigated the influence of calcitriol, the active form of vitamin D, on experimental autoimmune encephalomyelitis (EAE), an animal model akin to multiple sclerosis. Our study involved twenty-eight mice divided into four groups, allowing us to compare outcomes between those with and without EAE, as well as those receiving calcitriol treatment.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
Read More
9
Vitamin D3 may protect against MS
The role of vitamin D through SphK1/S1P in the regulation of MS progression.
Directly addresses vitamin D3 effects
We explored the effects of vitamin D3 on multiple sclerosis (MS) by examining its role in regulating a specific lipid called Sphingosine-1-phosphate (S1P), which is known to contribute to neuroinflammation and the progression of MS. In a series of carefully designed experiments, we looked at both the EAE model in rats, which mimics MS, and PC12 cells to understand how vitamin D3 may offer protective benefits against cellular damage.
Our findings indicated that vitamin D3 could alleviate symptoms of EAE in rats and reduce the severity of their condition. We observed that it also inhibited the expression of SphK1, which is responsible for producing S1P, leading to lower levels of this inflammatory mediator. In the laboratory environment, vitamin D3 significantly reduced cell death induced by S1P in PC12 cells, showing an improvement in cell attachment quality and overall health.
Additionally, vitamin D3 appeared to block pathways that are known to lead to inflammation and cell death. We noticed reductions in certain cytokines and apoptosis markers, which are associated with inflammatory responses. There was also an increase in a protein linked to nerve cell protection, suggesting vitamin D3 has multiple mechanisms through which it operates.
In summary, our research supports the idea that vitamin D3 has a protective effect against MS by lowering S1P levels and influencing several related pathways. This opens up promising avenues for vitamin D3 to be considered in combination therapies aimed at treating this challenging condition.
Our findings indicated that vitamin D3 could alleviate symptoms of EAE in rats and reduce the severity of their condition. We observed that it also inhibited the expression of SphK1, which is responsible for producing S1P, leading to lower levels of this inflammatory mediator. In the laboratory environment, vitamin D3 significantly reduced cell death induced by S1P in PC12 cells, showing an improvement in cell attachment quality and overall health.
Additionally, vitamin D3 appeared to block pathways that are known to lead to inflammation and cell death. We noticed reductions in certain cytokines and apoptosis markers, which are associated with inflammatory responses. There was also an increase in a protein linked to nerve cell protection, suggesting vitamin D3 has multiple mechanisms through which it operates.
In summary, our research supports the idea that vitamin D3 has a protective effect against MS by lowering S1P levels and influencing several related pathways. This opens up promising avenues for vitamin D3 to be considered in combination therapies aimed at treating this challenging condition.
Read More
8
Vitamin D3 may enhance therapies
Targeting aryl hydrocarbon receptor functionally restores tolerogenic dendritic cells derived from patients with multiple sclerosis.
Study complexity impacts vitamin D3 effects
We explored how vitamin D3 can influence the immune system in patients with multiple sclerosis (MS). Our study investigated the properties of monocytes, mature dendritic cells, and a specific type of tolerogenic dendritic cells derived from both active, treatment-naive MS patients and healthy donors.
Through a comprehensive analysis, we noted that the immune cells from MS patients displayed more pro-inflammatory characteristics compared to those from healthy individuals. Interestingly, when we treated these MS-derived cells with vitamin D3 and a compound called dimethyl fumarate (DMF), we observed a remarkable restoration of their tolerogenic properties.
In our experimental model using mice, the combination of DMF and vitamin D3-tolerogenic dendritic cells resulted in better outcomes than either treatment alone. This suggests that using vitamin D3 alongside DMF may provide a more effective approach to managing MS by potentially re-establishing immune tolerance without broad immunosuppression.
While our findings point to a promising combination therapy, the results underscore the need for further research to fully delineate the specific benefits of vitamin D3 in MS treatment.
Through a comprehensive analysis, we noted that the immune cells from MS patients displayed more pro-inflammatory characteristics compared to those from healthy individuals. Interestingly, when we treated these MS-derived cells with vitamin D3 and a compound called dimethyl fumarate (DMF), we observed a remarkable restoration of their tolerogenic properties.
In our experimental model using mice, the combination of DMF and vitamin D3-tolerogenic dendritic cells resulted in better outcomes than either treatment alone. This suggests that using vitamin D3 alongside DMF may provide a more effective approach to managing MS by potentially re-establishing immune tolerance without broad immunosuppression.
While our findings point to a promising combination therapy, the results underscore the need for further research to fully delineate the specific benefits of vitamin D3 in MS treatment.
Read More
8
Vitamin D3 enhances T cell tolerance
Myelin Oligodendrocyte Glycoprotein (MOG)35-55 Mannan Conjugate Induces Human T-Cell Tolerance and Can Be Used as a Personalized Therapy for Multiple Sclerosis.
Relevant but complicated context
We conducted an insightful exploration into how Vitamin D3, alongside other therapeutic factors, influences immune responses in individuals dealing with multiple sclerosis (MS). Our research investigated the effects of a specific peptide, MOG35-55, combined with mannan, in promoting tolerance among T cells—these being crucial in the context of autoimmune conditions like MS.
Our experiments involved developing different types of dendritic cells from the blood of both healthy individuals and MS patients. By exposing these cells to MOG35-55 and observing their interactions with T cells over multiple cycles, we noticed a remarkable shift in the immune environment. Particularly, the dendritic cells soaked in Vitamin D3 exhibited promising results in enhancing the tolerance of T cells, showing increased levels of specific markers associated with immune regulation.
What's noteworthy is that these Vitamin D3-treated dendritic cells led to the highest occurrence of T cells indicating active regulation and suppression of autoimmune responses. This finding suggests a potential path forward toward tailored therapies for MS that leverage the immune-modulatory properties of Vitamin D3.
In conclusion, while we observed the potential benefits of Vitamin D3 in this context, we must also highlight that its effect was part of a complex interplay with other factors. Our study lays the groundwork for developing personalized vaccines or treatments for multiple sclerosis, emphasizing the role of specific immune modulation.
Our experiments involved developing different types of dendritic cells from the blood of both healthy individuals and MS patients. By exposing these cells to MOG35-55 and observing their interactions with T cells over multiple cycles, we noticed a remarkable shift in the immune environment. Particularly, the dendritic cells soaked in Vitamin D3 exhibited promising results in enhancing the tolerance of T cells, showing increased levels of specific markers associated with immune regulation.
What's noteworthy is that these Vitamin D3-treated dendritic cells led to the highest occurrence of T cells indicating active regulation and suppression of autoimmune responses. This finding suggests a potential path forward toward tailored therapies for MS that leverage the immune-modulatory properties of Vitamin D3.
In conclusion, while we observed the potential benefits of Vitamin D3 in this context, we must also highlight that its effect was part of a complex interplay with other factors. Our study lays the groundwork for developing personalized vaccines or treatments for multiple sclerosis, emphasizing the role of specific immune modulation.
Read More
8
Vitamin D3 influences MS immune response
The immune cell transcriptome is modulated by vitamin D supplementation in people with a first demyelinating event participating in a randomized placebo-controlled trial.
Direct assessment of immune impact
We conducted a thorough investigation into the potential benefits of vitamin D3 supplementation for individuals who have experienced a first demyelinating event, which can be an early indication of multiple sclerosis (MS). Our study was a part of the PrevANZ trial and involved randomizing participants to receive varying doses of vitamin D—1000, 5000, or 10,000 international units—or a placebo, over a period of 12 weeks.
We focused on how these vitamin D3 supplements affected the gene expression of immune cells. After analyzing blood samples from 55 participants both at the beginning and end of the study, we observed that higher doses of vitamin D significantly influenced immune cell activity. Specifically, we found pathways linked to antigen presentation and viral responses became more active, while pathways associated with energy production and certain immune signals, like tumor necrosis factor-alpha and interleukin-17, were less active.
Overall, the results indicate that vitamin D3 supplementation can lead to an anti-inflammatory shift in immune gene expression, suggesting a potential protective role in the development of MS. This study supports the hypothesis that vitamin D3 could be an effective strategy, showing a dose-dependent relationship in immune response modulation.
We focused on how these vitamin D3 supplements affected the gene expression of immune cells. After analyzing blood samples from 55 participants both at the beginning and end of the study, we observed that higher doses of vitamin D significantly influenced immune cell activity. Specifically, we found pathways linked to antigen presentation and viral responses became more active, while pathways associated with energy production and certain immune signals, like tumor necrosis factor-alpha and interleukin-17, were less active.
Overall, the results indicate that vitamin D3 supplementation can lead to an anti-inflammatory shift in immune gene expression, suggesting a potential protective role in the development of MS. This study supports the hypothesis that vitamin D3 could be an effective strategy, showing a dose-dependent relationship in immune response modulation.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 6 Reviews
8.1
8.8
Supports brain health
Over 50? Take vitamin D3! It's excellent for bone health and prevents serious conditions like multiple sclerosis. The dosage works quickly, and I noticed positive effects soon after starting. Recommended for improving health!
8.8
Disease prevention
Insufficient vitamin D can lead to chronic illnesses like multiple sclerosis and cancer. I take D3 regularly, with higher doses in winter to maintain my health and prevent long-term issues.
8
Boosts immunity
Solar cell D3 is essential for everyone. It enhances immunity, reduces the risk of viral diseases, and is vital for various bodily functions. In our area, sunlight is limited, making D3 supplementation crucial. I prefer NOW Vitamin D3, as it offers excellent quality at a reasonable price.
Read More
8
Immunity enhancement
D3 is crucial for the immune system and reduces viral disease risks. It's synthesised in sunlight, so supplementation is important, especially during winter. I recommend NOW Vitamin D3 for its quality and value.
8
Reduces disease risks
Vitamin D3, known as the "solar cell", regulates immunity, reduces the risk of multiple sclerosis, and supports overall health. It’s vital for bones and essential in preventing various diseases.
